Over the years we have managed to build a solid team of software outsourcing professionals that come from various backgrounds and expand the creative potential of the company. The expertise that they posses embraces a wide range of custom programming skills involving the latest and most effective development technologies, such as .NET (ASP.NET, C#, VB.NET), XML and many more. This to a great extent defines the quality and reliability of the custom software applications that we develop.

Our collection of Indian paintings depicts Indian art at its best. We have divided our fine art prints into different categories such as Desi, which boasts the culture of India through outstanding Indian paintings of festivals, romantic scenes and peoples of India. Under the category Faith we have portrayed spiritual masters and great philosophers who have helped shape the world. Mera Bharat Mahan connects us to the great figures of Indian history. The Caricatures & Humorous Sketches are sure to bring a smile to your face. We have more on offer in other sections like Modern and A Tribute to the Masters. In the Abstract section we have an amazing collection. We also have Bollywood Posters. If you are looking for real Art then this is the site where you can buy amazing Indian Wall Art. Best possible value for your money. Our prints make ideal gifts…. Enjoy the gallery! 

All India Arts is a UK based company. All our wall hanging art prints are made from completely original Indian Paintings for which we hold world copyright. Our collection is unique and unmatchable.

Content Source: All India Arts

"This was extremely unexpected," says senior author Stuart A. Kornfeld, MD, the David C. and Betty Farrell Professor of Medicine. "Why would impairment in a lysosomal pathway lead to stuttering? We don't know the answer to that. Partly because we don't know very much about the mechanisms of speech, including which neurons in the brain are involved. So we can't fully explain stuttering, but now we have clues."

The research is available online in the Journal of Biological Chemistry

Genetic clues to stuttering were first identified in a paper published in theNew England Journal of Medicine in February 2010. In it, Dennis Drayna, PhD, a senior investigator with the National Institute on Deafness and Other Communication Disorders and a co-author on the current study, and his colleagues reported results of genetic studies on members of a large Pakistani family, many of whom stutter.

Among most of the stuttering family members, they found mutations in three genes involved in directing proteins to the lysosome. These same mutations were present in many unrelated individuals in Pakistan, North America and Europe who stutter, but not in those with normal speech.

"They found mutations in three genes that encode a pathway for directing newly made lysosomal enzymes to the lysosomes," Kornfeld says. "And it turned out to be a pathway we discovered years ago. So this is a nice collaboration."

Until now, one of the three genes, NAGPA, had not been implicated in any human disorder. This is where Kornfeld and Wang-Sik Lee, PhD, research instructor in medicine at Washington University, began their in-depth biochemical investigation of the mutations that Drayna's group identified.

NAGPA encodes an enzyme responsible for the last step in "addressing" proteins to the lysosome. Drayna's work identified three separate mutations in NAGPA in individuals who stutter. And according to Lee's biochemical analysis, all three of the mutations impaired the enzyme, but each did so in a different way. In general, mutations in a gene often cause the resulting protein to be folded into the wrong shape. Cells are very good at recognizing misfolded proteins and destroying them.

In this case, Lee's biochemical analysis shows that two mutations appear to trap the proteins in the cell's protein manufacturing center, though some get out before being destroyed.

"It's not an all-or-nothing thing," Kornfeld says. "Of the material that does get out, its activity is normal."

But the third mutation causes a larger folding problem and the protein is destroyed just minutes after being made.

Such findings offer a glimpse at possible future therapies for stuttering. For two of the mutations at least, the problem is not that the protein can't function, but rather that it can't get out of the cell's protein manufacturing center and go to the intracellular site where it acts to direct proteins to lysosomes. If some compound can be found that helps the protein escape, Lee's work suggests that it would function normally. But Kornfeld cautions that this type of therapy for stuttering is a long way off.

"There are billions of neurons in the brain, and we have very little idea which neurons are involved in speech," he says. "Our main finding is that these three mutations in NAGPA in people with persistent stuttering all have harmful effects. This is biochemical evidence that these mutations are meaningful, and not just markers of some other genetic change that is the real cause."

Having described the three harmful mutations in NAGPA, Kornfeld's group is now performing biochemical analyses on the other two mutated genes Drayna's group identified: GNPTAB and GNPTG. Drayna and his colleagues estimate that these three mutated genes account for only about 10 percent of people who stutter with a family history. As such, they are continuing the search for additional genes responsible for stuttering.

This work was supported by grants from the National Institutes of Health (NIH) and from the National Institute on Deafness and Other Communication Disorders, which is a part of the NIH.

News Source: http://esciencenews.com/articles/2011/11/23/surprising.pathway.implicated.stuttering

The blog has a lone opening article wriiten by Hazare – 'Curbing Corruption and Holistic Development of Villages – These Two Things are Important for India's Development'.

The activist can be found on: annahazaresays.indiaagainstcorruption.org

Unlike an earlier blog which was tri-lingual — in Marathi, Hindi and English — Hazare's new blog is in Hindi and English.

However, the writers who will air Hazare's views are not known.

A brief announcement on the old blog, posted nearly two weeks ago, said the blog had been closed.

Two days ago, the Lonavala-based Celebrity Wax Museum unveiled a wax statue of Hazare which was thrown open to the people at its Varsoli exhibition centre on the outskirts of the hill-station.

From the end of november to christmas, there are many movies lined-up for release, namely

• Desi Boyz
• The Dirty Picture
• Ladies Vs. Ricky Bahl
• Don-2

Many Predictions are being there about, which movie gonna rule the audience and fetch more and more people to screens. The movie makers and even the audience have high expectation from their favourite casts, to get the best results at the end of the year.

Desi Boyz

Cast- Akshay Kumar, John Abraham, Chitragandha Sen Gupta, Deepkia Padukone.

Release Date- 25th Nov 2011.

The Dirty Picture

Cast- Naseeruddin Shah, vidya Balan, Emraan Hashmi, Tusshar Kapoor.

Release Date- 02nd Dec 2011.

Ladies Vs. Ricky Bahl

Cast- Ranvir Kapoor, Anushka Sharma.

Release Date- 09th Dec 2011.

Don-2

Cast- Shahrukh Khan, Priyanka Chopra, Om Puri, Lara Dutta, Boman Irani.

Release Date- 25th Dec 2011.

But On the first day, it was real shock for Team India , The WI openers gave a good start, playing very watchfully all of the Indian Bowlers. Both the openers got their fifties. After them, the middle order did their task and all batsman from the middle order scoring fifties and doing useful partnership kept Indian bowlers away from fetching wickets.

On the Second Day of the test, it was the big day for the man who is known to be the shadow of the Brian Lara, Darren Bravo scored a ton which helped WI reach a healthy total of 575 runs. Bravo made 166, while other middle order batsmen were also impressive and played very well.

Other than Bravo, Kirk Edwards made 86, Keirren Powell made 81, Marlon Samuels made 61, after the middle order, the lower middle order and the tail enders collapsed and at the end of the WI were in good position with 575/9, and still undeclared.

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